Biosketch

Peter R. Mouton, Ph.D. 
President & Chief Scientific Officer, 
SRC Biosciences (Stereology Resource Center)
1810 W. Kennedy Blvd
Tampa, FL 

Education

  • NIH Postdoctoral Fellowship in Neuropathology, Pathology Department, The Johns Hopkins University School of Medicine, Baltimore, MD. (Prof. Donald L. Price, M.D.).
  • Postdoctoral Fellowship in Unbiased Stereology, University of Copenhagen, Denmark (Prof. dr. Hans J. G. Gundersen).
  • Predoctoral Fellowship in Neurobiology (American-Scandinavian Foundation), Karolinska Institute, Stockholm, Sweden (Prof. dr. Lars Olson).
  • Ph.D. Neurobiology. Dissertation: “Alzheimer-Like Neurochemical, Behavioral and Morphological Changes in the Rat Brain Following Intracortical AF64A” (Profs. Marvin Alvarez, Gary Arendash), USF Colleges of Medicine and Natural Sciences, Tampa, FL.
  • Master’s Degree (MA), The Johns Hopkins University, Baltimore, MD
  • Bachelor Degree (BS Biology), College of Natural Sciences, USF, Tampa, FL.
  • Bachelor Degree (BA Chemistry), College of Natural Sciences, USF, Tampa, FL. 

Current Positions

  • 2003-present: President & Chief Scientific Officer, SRC Biosciences (Stereology Resource Center, Inc.), 1810 W. Kennedy Blvd, Tampa, FL
  • 2010-present: Professor of Stereology & Computer Sciences, College of Engineering, University of South Florida, Tampa, FL (Courtesy Appointment).
  • 2016-present: Standing Study Section Member: ETTN-H (11B ), Drug Discovery for Aging, Neuropsychiatric and Neurological Diseases. NIH Center for Scientific Review.
  • 2017-present: Member Editorial Board, Journal of Chemical Neuroanatomy
  • 2018-present. Professorem Hospitem (Visiting Professor), 4EU Alliance, Charles University at Prague, Czech Republic.
  • 2018-2021: Fulbright Specialist, Bureau of Education & Cultural Affairs, U.S. Department of State.

Past Positions

  • Director Stereology Core Facility, Gerontology Research Center, National Institute on Aging, Baltimore, MD.
  • Assistant Professor, Faculty, Pathology Department, The Johns Hopkins University School of Medicine, Baltimore, MD.

Grant Awards & Contracts

SRC Biosciences is funded by research grants and outsourcing contracts to study the biological basis of diseases; provide training to individuals and groups; and, develop technology to enhance health and well-being. Proprietary information outside the public domain about CRO contracts with academic researchers, government agencies and private industry is not listed below.

National Science Foundation (NSF)
Title: Microscope-based Technology For Automatic Cell Analysis Using Unbiased Methods.
Project Role: Peter R. Mouton, Principal Investigator
Award Type: STTR Phase II Award: NSF # 1926990
Duration: 01 September 2019 – 31 August 2021
Project Goal: Develop and validate deep learning neural networks for automatic stereology of biological structure on stained tissue sections.

National Institute on Aging (NIH)
Project Title: Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease.
Project Role: Peter R. Mouton, Principal Investigator, Neuropathology Subaward
Award Type: R01 National Institute on Aging (Mobley, William, PI)
Duration: 01 May 2018 – 31 January 2023
Project Aims: 1. Detail the time of onset of neurodegeneration in the Dp16 model of AD-DS and Line 41 AD model using unbiased stereology. 2. Examine the effect of BPN15606 treatment before and after onset of neurodegeneration in the AD-DS model, the AD/cerebral amyloidosis model and the Line 41 mouse model.

National Institutes Of Aging (NIH)
Project Title:  Antisense Oligonucleotides Targeting APP to Prevent Neurodegeneration in Models of Down Syndrome and Alzheimer’s disease.
Project Role: Peter R. Mouton, Principal Investigator, Neuropathology Subaward
Award Type: R01 National Institute on Aging (Mobley, William, PI)
Duration: 01 September 2018 to 31 August 2023
Project Goal: Assess the ability of ASO targeting to mitigate AD neuropathology in mouse models of AD and Down syndrome.

Florida High Tech Corridor Grant Program
Award Title: Applications of Deep Learning and Automatic Stereology to Assess Treatments for Alzheimer’s Disease.
Project Role: Co-PI (Mouton/Goldgof))
Duration: 01 September 1, 2019 – August 31, 2021
Project Goal: Apply artificial intelligence to stereology analysis of Alzheimer’s disease neuropathology.

U.S. Department of State
Award Title: Fulbright U.S. Scholar Award (Fulbright Specialist)
Project Role: Principal Investigator
Duration: 09 April 2018 – 08 April 2021
Project Goal: Provide the international bioscience community with professional stereology support through on-site training, collaboration and consultation.

National Science Foundation (NSF)

Title: Grant Support for Spring 2019 NSF I-Corps Workshop at USF (Tampa, FL).
Project Role: Principal Investigator
Duration September-November 2019.
Project Goal: Use team-based customer discovery to commercialize biotechnology for the global bioscience community.

 


Selected Publications (> 100 total)

Peer-reviewed Science Journals

  • Goulding, D., Kraft, A., Mouton, P.R., McPherson, C.A., Avdoshina, V., Mocchetti, I., Harry, G.J. Age-related decrease in tyrosine hydroxylase immunoreactivity in the substantia nigra and region-specific changes in microglia morphology in HIV-1 Tg rats. Neurotoxicology Research July 8, 2019. doi: 10.1007/s12640-019-00077.
  • Walters, K., Boucher, M., Boucher, G.G., Opsahl, A.C., Mouton, P.R., Liu, C.-N., Ritenour, C.R., Kawabe, T.T., Pryski, H.N., Somps, C.J. No evidence of neurogenesis in adult rat sympathetic ganglia following guanethidine-induced neuronal necrosis. Toxicologic Pathology, April 2019. doi: 10.1177/0192623319843052.
  • Klebe, D., Tribewal, M., Vanaparthy, R., Varghese, M., Cheng, B., Mouton, P.R., Velishek, J., Dobrenis, K., Hof, P.R., and Ballabh, P. Reduced hippocampal dendrite branch, spine density and cognitive function in preterm rabbits and reversal with estrogen or TrkB agonist. Cerebral Cortex, March 16, 2019. doi: 10.1093/cercor/bhz033
  • Phoulady, H.A., Goldgof, D., Lawrence O. Hall, L.O., Mouton, P.R. Automatic Ground Truth for Deep Learning Stereology of Immunostained Neurons and Microglia in Mouse Neocortex. J. Chemical Neuroanatomy, 96: 1-7, 2019. doi: 10.1016/j.jchemneu.2019.02.00.
  • Alahmari, S., Goldgof, D., Hall, D. Phoulady, H.A. Patel, R., Mouton, P.R. Automated Counts of Stained Cells by Deep Learning and Unbiased Stereology. J Chem Neuroanat, 96:94-101, 2019. doi: 10.1016/j.jchemneu.2018.12.010.
  • Phoulady, H.A., Goldgof, D., Hall, L.O., Nash, K.N., Mouton, P.R. Automatic Stereology of Mean Nuclear Size of Neurons using an Active Contour Framework. J Chem Neuroanat, 96:110-115, 2019. doi: 10.1016/j.jchemneu.2018.12.012.
  • Mouton, P.R., Phoulady, H.A., Goldgof, D., Hall, L.O., Gordon, M., Morgan, D. Unbiased estimation of cell number using the automatic optical fractionator. J Chem Neuroanat, 80:1-8, 2017. doi: 10.1016/j.jchemneu.2018.12.012.
  • Phoulady, H.A., Goldgof, D.B., Hall, L.O., Peter R. Mouton. A framework for nucleus and overlapping cytoplasm segmentation in cervical cytology extended depth of field and volume images. Computerized Medical Imaging and Graphics, Volume 59,  Pages 38-49, July 2017.
  • Mouton, P.R. Unbiased Stereology Of Neural Systems: From Normal Aging To Mental Illness And Neurodegenerative Diseases (Editor). Special issue, J Chem Neuroanat, Volume 76, 2016.
  • Marcek, J., Okerberg, C., Liu, C.N., Potter D., Butler, P., Boucher, M., Peter R. Mouton, Nyengaard, J.R., Somps, C. Anti-NGF monoclonal antibody mu Mab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats. J Chem Neuroanat. 76: 133 2016.
  • Weise, C. M., Peter R. Mouton, Eschbacher, J., Coons, S. W., Krakoff, J. A Post-Mortem Stereological Study Of Striatal Cell Number In Human Obesity. Obesity, 23(1):100-4, 2015.
  • Mouton, P.R., Sobin, C. Developing a census of brain cells for the corticoendogram of human consciousness. J Chem Neuroanatomy, 2015.
  • Harry, G.J., Hooth, M.J., Vallant, M., Behl, M., Travlos, G.S., Howard, J.L., Price, C.J., McBride, S., Mervis, R., Peter R. Mouton, Neurodevelopmental Effects Of Gestational And Perinatal Thyroid Disruption In Rats. Toxics, 2, 496-532, 2014.
  • Stoner, R., Chow, M.L., Boyle, M.P., Sunkin, S.M., Peter R. Mouton, Roy, S., Wynshaw-Boris, A., Colamarino, S., Lein, E.S., Courchesne, E. Discrete Patches of Laminar Disorganization in Young Autistic Neocortex. New England Journal of Medicine, January, 2014.
  • Manaye, K.F., Peter R. Mouton, Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. AGE 35: 139-147, 2013.
  • Selenica, M-L. B., Alvarez, J.A., Nash, K.R., Lee, D.C., Cao, C., Lin, X., Reid, P., Peter R. Mouton, Morgan, D.,  Gordon, M.N. Diverse Activation Of Microglia By Chemokine (C-C Motif) Ligand 2 Overexpression In Brain. Journal Of Neuroinflammation, 10:86, 2013.
  • Elozory, D.T., Bonam, O.P., Kramer, K., Goldgof, D., Hall, L., Mangual, O., Peter R. Mouton, Automatic Section Thickness Determination Using An Absolute Gradient Focus Function. J Microsc, 248(3): 245-59, 2012.
  • Peter R. Mouton, Kelley-Bell, B., Tweedie, D., Spangler, E., Perez, E., Carlson, O.D., Short, R.G., Decabo, R., Chang, J., Ingram, D.K., Li, Y., Greig, N.H. Effects Of Age And LPS-Mediated Inflammation On Central Catecholaminergic Neuron Number In B6 Mice. Neurobiology Of Aging, 423:27-36, 2012.
  • Manaye, K.F., Peter R. Mouton, Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Alzheimer’s Type Neuron Loss In Locus Coeruleus Of Triple Transgenic Mice. AGE, November 30, 2011.
  • Courchesne, E., Peter R. Mouton, Calhoun, M.E., Semendeferi, K., Ahrens-Barbeau, C., Carter, C., Pierce, K. Neuron Number And Size In Prefrontal Cortex Of Children With Autism. JAMA, 306 (18):2001-10, 2011.
  • Manaye, K.F., Kalifa, S., Drew, A.C., Edossa, A., Lei, D-L, Ingram, D.K., Peter R. Mouton. 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. Journal of Alzheimer’s Disease, 23:629-39, December 2010.
  • Peter R. Mouton, Chachich, M.E., Quigley, C., Spangler, E., Ingram, D.K. Caloric Restriction Attenuates Cortical Amyloidosis In A Double Transgenic Mouse Model Of Alzheimer’s Disease. Neuroscience Lett 464:184-7, 2009.
  • Burke, M, Zangenehpour, S, Peter R. Mouton, Ptito, M. Knowing What Counts: Unbiased Stereology In The Non-Human Primate Brain. J Vis Exp. 2009 May 14; (27) 1262-1266. Video: Http://Www.Jove.Com/Index/Details.Stp?ID=1262.
  • Duffy, K.B, Spangler E.L., Devan B.D., Guo Z., Bowker J.L., Janas, A.M., Hagepanos, A., Minor, R.K., Decabo R., Peter R. Mouton, Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. A Blueberry-Enriched Diet Provides Cellular Protection Against Oxidative Stress And Reduces A Kainate-Induced Learning Impairment In Rats. Neurobiol Aging. 29:1680-9, 2008.
  • Manaye, K.F., Wang, P., O’Neil, J., Huafu, S., Tizabi, Y., Thompson, N., Ottinger, M.A., Ingram, D.K., Peter R. Mouton. Neuropathological Quantification Of Dtg APP/PS1. AGE 29:87-96, 2007.
  • O’Neil, J.N., Peter R. Mouton, Tizabi Y., Ottinger, M.A., Lei, D-L., Ingram, D.K., Manaye, K.F. Catecholaminergic Neuron Number In Locus Coeruleus Of Aged Female Dtg App/Ps1 Mice. J. Chem.Neuroanat. 34(3-4): 102-7, 2007.
  • Perry, T.A., Holloway, H.W., Weerasuriya, A., Peter R. Mouton, Duffy, K., Mattison J.A. Evidence Of GLP-1-Mediated Neuroprotection In An Animal Model Of Pyridoxine-Induced Peripheral Sensory Neuropathy. Exp Neurol 203:293-301, 2007.

Peer-reviewed Books & Book Chapters

Peer-reviewed Conference Papers

  • Alahmari, S., Goldgof, D., Hall, D. Dave, P., Phoulady, H.A. Patel, R., Peter R. Mouton. Iterative Deep Learning Based Unbiased Stereology With Human-in-the-Loop. 17th IEEE International Conference on Machine Learning and Applications, Orlando, Florida, December 17-20, 2018.
  • Phoulady, H. A., Mouton, P.R.  New cervical cytology dataset for nucleus detection and image classification (Cervix93) and methods for cervical nucleus detection. Proc. IEEE International Symposium on Biomedical Imaging, November, 2018.
  • Phoulady, H.A., Goldgof, D., Hall, L.O., Peter R. Mouton. Histopathology Image Segmentation with Hierarchical Multilevel Thresholding, In Proceedings of the SPIE Medical Imaging on Digital Pathology, San Diego, CA, 2016.
  • Phoulady, H. A., Peter R. Mouton.  New cervical cytology dataset for nucleus detection and image classification (Cervix93) and methods for cervical nucleus detection. IEEE International Symposium on Biomedical Imaging, arXiv:1811.09651, November 23, 2018.
  • Phoulady, H.A., Goldgof, D.B., Hall, L.O., Peter R. Mouton. A Framework for Nucleus and Overlapping Cytoplasm Segmentation in Cervical Cytology Extended Depth of Field and Volume Images. Computerized Medical Imaging and Graphics, 59: 38-49, 2017.
  • Peter R. Mouton, Ahmari, S.A., Phoulady, H.A., Hall, L.O., Goldgof, D.B. High-Speed Stereology Analysis Of Neural Structures By Fully Automatic Stereology Technology (FAST). 50th International Congress of the Czech Anatomical Society, Pilsen, Czech Republic, September 2017.
  • Phoulady, H.A., Goldgof, D.B., Hall, L.O., and Peter R. Mouton. A new approach to detect and segment overlapping cells in multi-layer cervical cell volume images. Proceedings of the International Symposium on Biomedical Imaging (IEEE), Prague, Czech Republic, April 2016.
  • Chaudhury, B., Kramer, K., Elozory, D., Hernandez, G., Goldgof, D., Hall, L.O., Peter R. Mouton. A Novel Algorithm For Automated Counting Of Stained Cells On Thick Tissue Sections. In 25th International Symposium on Computer-based Medical Systems (CBMS) (Rome, Italy), pp. 1-6. IEEE, 2012.
  • Bonam, O., Elozory, D., Kramer, K., Goldgof, D., Hall, L.O., Mangual, O. Peter R. Mouton. Toward automated quantification of biological microstructures using unbiased stereology, Proc. SPIE, vol.7963, 2011.

 


Selected Awards, Honors, Patents (since 1997)