Peter R. Mouton Biosketch

 Education Undergraduate, Graduate, Postdoctoral
  • Bachelor’s Degree in Biology, University of South Florida (USF), Tampa, FL.
  • Bachelor’s Degree in Chemistry, USF, Tampa, FL.
  • Masters Degree (Prof. Edward Perlman), The Johns Hopkins University Krieger School of Arts & Sciences, Baltimore, MD.
  • Predoctoral Fellowship (Prof. dr. Lars Olson), Neurobiology, Karolinska Institute, Stockholm, Sweden.
  • Ph.D., Neurobiology (Prof. Marvin Alvarez), USF Colleges of Medicine and Natural Sciences, Tampa, FL.
  • Postdoctoral Fellowship, Neurostereology (Prof. dr. Hans J. Gundersen), University of Copenhagen, Copenhagen, Denmark.
  • Postdoctoral Fellowship, Neuropathology (Prof. Donald L. Price, M.D.), The Johns Hopkins University School of Medicine, Baltimore, MD.

Mouton,Peter BRD_cover_2014 copy

Current/ Past Positions

Director & Chief Scientist, SRC Biosciences (Stereology Resource Center, Inc.) Tampa, FL (1995-present).

Professor of Stereology, Pathology & Cell Biology and The Byrd Alzheimer’s Disease Center and Research Institute, USF College of Medicine, Tampa, FL. (2010-present)

Director, Stereology Laboratory, Gerontology Research Center, National Institute on Aging, Baltimore, MD (2000-2010).

Assistant Professor, Pathology Department, The Johns Hopkins School of Medicine, Baltimore, MD (1994-2000).

 

Selected Awards, Honors, Patents (past 20 years)

  • 2017-present. Member, Editorial Advisory Board, Journal of Chemical Neuroanatomy, Elsevier Press.
  • 2016-present. Member, NIH Study Section: Drug Discovery for Aging, Neuropsychiatric and Neurological Diseases [ETTN (M11)].
  • 2015. First Place, Image Segmentation Challenge on Overlapping Cytology. An approach for overlapping cell segmentation in multi-layer cervical cell volumes. IEEE ISBI, Brooklyn, NY.
  • 2017-present. International and U.S. Patents for Automatic Stereological Analysis of Biological Tissue (2017); and Automatic Screening of Cervical Cancer Using Unbiased Stereology.
  • 2014. Florida High Tech Magazine’s Top Technology Entrepreneur for Stereologer, an NIH-funded computerized stereology system.
  • 2009. Faculty Mentor Award from Office of the Provost, The Johns Hopkins University, Baltimore, MD.
  • 2003-present. Principal Investigator of federal (NIH) research grants.
  • 2001-2011. Official United States Representative, The International Society For Stereology.
  • 1997-2005. Faculty-to-Teacher Program, The Johns Hopkins University and Baltimore City Schools.
  • 1999. Ruth M. Salta Award for Outstanding Alzheimer’s Disease Research.
  • 1998. Nathan Shock Award for Aging Research, Young Investigator Award.


Selected Peer-reviewed Books, Articles and Invited Book Chapters/Conference Papers

Journal Articles (past 10 years, > 80 total)

Phoulady, H.A., Goldgof, D., Hall, L.O., Mouton, P.R.. Histopathology Image Segmentation with Hierarchical Multilevel Thresholding. J Chem Neuroanat,  in press.

Phoulady, H.A., Goldgof, D.B., Hall, L.O., Mouton, P.R. A Framework for Nucleus and Overlapping Cytoplasm Segmentation in Cervical Cytology Extended Depth of Field and Volume Images. Computerized Medical Imaging and Graphics, in press.

Mouton, P.R., Phoulady, H.A., Goldgof, D., Hall, L.O., Gordon, M., Morgan, D. Unbiased estimation of cell number using the automatic optical fractionator. J Chem Neuroanat, 80:1-8, 2017.

Mouton, P.R. Unbiased Stereology Of Neural Systems: From Normal Aging To Mental Illness And Neurodegenerative Diseases. J Chem Neuroanat, Volume 76, October 2016.

Marcek, J., Okerberg, C., Liu, C.N., Potter D., Butler, P., Boucher, M., Mouton, P.R., Nyengaard, J.R., Somps, C. Anti-NGF monoclonal antibody mu Mab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats. J Chem Neuroanat. 76: 133 2016.

Weise, C. M., Mouton, P. R., Eschbacher, J., Coons, S. W., Krakoff, J. A Post-Mortem Stereological Study Of Striatal Cell Number In Human Obesity. Obesity, 23(1):100-4, 2015.

Mouton, P.R., Sobin, C. Developing a census of brain cells for the corticoendogram of human consciousness. J Chem Neuroanatomy, 2015.

Harry, G.J., Hooth, M.J., Vallant, M., Behl, M., Travlos, G.S., Howard, J.L., Price, C.J., McBride, S., Mervis, R., Mouton, P.R. Neurodevelopmental Effects Of Gestational And Perinatal Thyroid Disruption In Rats. Toxics, 2, 496-532, 2014.

Stoner, R., Chow, M.L., Boyle, M.P., Sunkin, S.M., Mouton, P.R., Roy, S., Wynshaw-Boris, A., Colamarino, S., Lein, E.S., Courchesne, E. Discrete Patches of Laminar Disorganization in Young Autistic Neocortex. New England Journal of Medicine, January, 2014.

Manaye, K.F., Mouton, P.R., Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. AGE 35: 139-147, 2013.

Selenica, M-L. B., Alvarez, J.A., Nash, K.R., Lee, D.C., Cao, C., Lin, X., Reid, P., Mouton, P.R., Morgan, D.,  Gordon, M.N. Diverse Activation Of Microglia By Chemokine (C-C Motif) Ligand 2 Overexpression In Brain. Journal Of Neuroinflammation, 10:86, 2013.

Elozory, D.T., Bonam, O.P., Kramer, K., Goldgof, D., Hall, L., Mangual, O., Mouton, P.R. Automatic Section Thickness Determination Using An Absolute Gradient Focus Function. J Microsc, 248(3): 245-59, 2012.

Mouton, P.R., Kelley-Bell, B., Tweedie, D., Spangler, E., Perez, E., Carlson, O.D., Short, R.G., Decabo, R., Chang, J., Ingram, D.K., Li, Y., Greig, N.H. Effects Of Age And LPS-Mediated Inflammation On Central Catecholaminergic Neuron Number In B6 Mice. Neurobiology Of Aging, 423:27-36, 2012.

Manaye, K.F., Mouton, P.R., Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Alzheimer’s Type Neuron Loss In Locus Coeruleus Of Triple Transgenic Mice. AGE, November 30, 2011.

Courchesne, E., Mouton, P.R., Calhoun, M.E., Semendeferi, K., Ahrens-Barbeau, C., Carter, C., Pierce, K. Neuron Number And Size In Prefrontal Cortex Of Children With Autism. JAMA, 306 (18):2001-10, 2011.

Manaye, K.F., Kalifa, S., Drew, A.C., Edossa, A., Lei, D-L, Ingram, D.K., Mouton, P.R. 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. Journal of Alzheimer’s Disease, 23:629-39, December 2010.

Mouton, P.R., Chachich, M.E., Quigley, C., Spangler, E., Ingram, D.K. Caloric Restriction Attenuates Cortical Amyloidosis In A Double Transgenic Mouse Model Of Alzheimer’s Disease. Neuroscience Lett 464:184-7, 2009.

Burke, M, Zangenehpour, S, Mouton PR, Ptito, M. Knowing What Counts: Unbiased Stereology In The Non-Human Primate Brain. J Vis Exp. 2009 May 14; (27) 1262-1266. Video: Http://Www.Jove.Com/Index/Details.Stp?ID=1262.

Duffy, K.B, Spangler E.L., Devan B.D., Guo Z., Bowker J.L., Janas, A.M., Hagepanos, A., Minor, R.K., Decabo R., Mouton, P.R., Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. A Blueberry-Enriched Diet Provides Cellular Protection Against Oxidative Stress And Reduces A Kainate-Induced Learning Impairment In Rats. Neurobiol Aging. 29:1680-9, 2008.

Manaye, K.F., Wang, P., O’Neil, J., Huafu, S., Tizabi, Y., Thompson, N., Ottinger, M.A., Ingram, D.K., Mouton, P.R. Neuropathological Quantification Of Dtg APP/PS1. AGE 29:87-96, 2007.

O’Neil, J.N., Mouton, P.R., Tizabi Y., Ottinger, M.A., Lei, D-L., Ingram, D.K., Manaye, K.F. Catecholaminergic Neuron Number In Locus Coeruleus Of Aged Female Dtg App/Ps1 Mice. J. Chem.Neuroanat. 34(3-4): 102-7, 2007.

Perry, T.A., Holloway, H.W., Weerasuriya, A., Mouton, P.R., Duffy, K., Mattison J.A. Evidence Of GLP-1-Mediated Neuroprotection In An Animal Model Of Pyridoxine-Induced Peripheral Sensory Neuropathy. Exp Neurol 203:293-301, 2007.

 

Books

Mouton, P.R., NeurostereologyWiley-Blackwell Press, Boston, 280 pages, November 2013.

Mouton, P.R. Unbiased Stereology: A Concise Guide. The Johns Hopkins University Press, Baltimore, August, 2011.

Mouton PR. Principles And Practices Of Unbiased Stereology: An Introduction For Bioscientists. The Johns Hopkins University Press, Baltimore, Maryland, May 2002.

 

Invited Book Chapters

Mouton, P.R. Quantitative Anatomy Using Unbiased Stereology, in CRC Handbook of Imaging in Biological Mechanics (Corey Geu and Guy Genin, eds), Taylor & Francis Press, London, 579 pp, October 27, 2014.

Mouton, P.R. Applications Of Unbiased Stereology To Neurodevelopmental Toxicology, In Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies And Mechanisms (C. Wang And W. Slikke, Eds), John Wiley & Sons, Hoboken, N.J. pg. 53-77, 2011.

Mouton, P.R., Gordon, M. Stereological And Image Analysis Techniques For Quantitative Assessment Of Neurotoxicology. In Neurotoxicology, 3rd Edition, Target Organ Toxicology Series, G. Jean Harry, Hugh A. Tilson, (Eds), Taylor & Francis Press, London And New York, pp. 243-267, March 2010.

Mouton, P.R. Applications Of Modern Stereology To Quantitative Microscopy, In Microscopy And Microanalysis, L.N. Brewer, S. Mackernan, J.P. Shields, et al., (Eds.), Cambridge University Press, London, Pp. 1526-1527, 2009.

Sisodia, S., Thinakaren, G., Van Koch, C., Slunt, H., Roskams, J., Kitt, C.A., Masliah, E., Koliatosos, V., Mouton P.R., Martin., L.J., Reed, R., Ronnett, G.V., Zheng, H., Van Der Ploeg, L., Price, D.L. In-Vivo Biology Of APP And Its Homologues. In Neurodegenerative Diseases: Molecular And Cellular Mechanisms And Therapeutic Approaches. (Gary Fiskum, Ed.), Plenum, New York. 485 Pp, 1996.

 

Invited Conference Papers 

Mouton, P.R., Ahmari, S.A., Phoulady, H.A., Hall, L.O., Goldgof, D.B. High-Speed Stereology Analysis Of Neural Structures By Fully Automatic Stereology Technology (FAST). 50th International Congress of the Czech Anatomical Society, Pilsen, Czech Republic, September 2017.

Phoulady, H.A., Goldgof, D.B., Hall, L.O., and Mouton, P.R. A new approach to detect and segment overlapping cells in multi-layer cervical cell volume images. Proceedings of the International Symposium on Biomedical Imaging (IEEE), Prague, Czech Republic, April 2016.

Chaudhury, B., Kramer, K., Elozory, D., Hernandez, G., Goldgof, D., Hall, L.O., Mouton, P.R. A Novel Algorithm For Automated Counting Of Stained Cells On Thick Tissue Sections. In 25th International Symposium on Computer-based Medical Systems (CBMS) (Rome, Italy), pp. 1-6. IEEE, 2012.

Bonam, O., Elozory, D., Kramer, K., Goldgof, D., Hall, L.O., Mangual, O. Mouton, P.R. Toward automated quantification of biological microstructures using unbiased stereology, Proc. SPIE, vol.7963, 2011.