Curriculum Vitae

 Peter R. Mouton, Ph.D. Education
  • Bachelor’s Degree in Biology, University of South Florida (USF), Tampa, FL.
  • Bachelor’s Degree in Chemistry, USF, Tampa, FL.
  • Masters Degree (Prof. Edward Perlman), The Johns Hopkins University Krieger School of Arts & Sciences, Baltimore, MD.
  • Predoctoral Fellowship (Prof. dr. Lars Olson), Neurobiology, Karolinska Institute, Stockholm, Sweden.
  • Ph.D., Neurobiology (Prof. Marvin Alvarez), USF Colleges of Medicine and Natural Sciences, Tampa, FL.
  • Postdoctoral Fellowship, Neurostereology (Prof. dr. Hans J. Gundersen), University of Copenhagen, Copenhagen, Denmark.
  • Postdoctoral Fellowship, Neuropathology (Prof. Donald L. Price, M.D.), The Johns Hopkins University School of Medicine, Baltimore, MD.

Mouton,Peter BRD_cover_2014 copy

Current/ Past Positions

Director & Chief Scientist, Stereology Resource Center, Tampa-St. Petersburg, FL, Baltimore MD-Washington DC (1995-present).

Professor of Stereology, Pathology & Cell Biology and The Byrd Alzheimer’s Disease Center and Research Institute, USF College of Medicine, Tampa, FL. (2010-present)

Director, Stereology Laboratory, Gerontology Research Center, National Institute on Aging, Baltimore, MD (2000-2010).

Assistant Professor, Pathology Department, The Johns Hopkins School of Medicine, Baltimore, MD (1994-2000).

 

Selected Awards, Honors, Patents

  • First Place, Image Segmentation Challenge on Overlapping Cytology. An approach for overlapping cell segmentation in multi-layer cervical cell volumes. IEEE ISBI, Brooklyn, NY, March 2015.
  • 2014 Florida High Tech Magazine’s Top Technology Entrepreneur for Stereologer, an NIH-funded computerized stereology system.
  • International and U.S. Patents for 1) Automatic Stereological Analysis of Biological Tissue (2012); and 2) Automatic Screening of Cervical Cancer Using Unbiased Stereology (2015).
  • Standing Study Section Member,Drug Discovery for Aging, Neuropsychiatric and Neurological Diseases ( NIH, ETTN, M11).
  • Official United States Representative, The International Society For Stereology (2001-11)
  • Faculty-to-Teacher Program, The Johns Hopkins University and Baltimore City Schools (1997-2005).
  • Faculty Mentor Award from Office of the Provost, The Johns Hopkins University, Baltimore, MD (2009).
  • Ruth M. Salta Award for Outstanding Alzheimer’s Disease Research (1999).
  • Nathan Shock Award for Aging Research, Young Investigator Award (1998).
  • Principal Investigator of federal (NIH) and private research grants and contracts (1988-present).

Selected Books, Chapters, and Articles

Mouton, P.R., Phoulady, H.A., Goldgof, D., Hall, L.O., Gordon, M., Morgan, D. Unbiased estimation of cell number using the automatic optical fractionator. J Chem Neuroanat, December 2016 (e-print).

Mouton, P.R. (author/editor) Unbiased Stereology Of Neural Systems: From Normal Aging To Mental Illness And Neurodegenerative Diseases. J Chem Neuroanat, Volume 76, October 2016.

Marcek, J., Okerberg, C., Liu, C.N., Potter D., Butler, P., Boucher, M., Mouton, P.R., Nyengaard, J.R., Somps, C. Anti-NGF monoclonal antibody mu Mab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats. J Chem Neuroanat. 76: 133 2016.

Phoulady, H.A., Goldgof, D.B., Hall, L.O., and Mouton, P.R. A new approach to detect and segment overlapping cells in multi-layer cervical cell volume images. Proceedings of the International Symposium on Biomedical Imaging (IEEE), Prague, Czech Republic, April 2016.

Mouton, P.R., Sobin, C. Developing a census of brain cells for the corticoendogram of human consciousness. Journal of Chemical Neuroanatomy, 2015 Oct 27.

Weise, C. M., Mouton, P. R., Eschbacher, J., Coons, S. W., Krakoff, J. A Post-Mortem Stereological Study Of Striatal Cell Number In Human Obesity. Obesity, 23(1):100-4, 2015.

Mouton, P.R. Quantitative Anatomy Using Unbiased Stereology, in CRC Handbook of Imaging in Biological Mechanics (Corey Geu and Guy Genin, eds), Taylor & Francis Press, London, 579 pp, October 27, 2014.

Harry, G.J., Hooth, M.J., Vallant, M., Behl, M., Travlos, G.S., Howard, J.L., Price, C.J., McBride, S., Mervis, R., Mouton, P.R. Neurodevelopmental Effects Of Gestational And Perinatal Thyroid Disruption In Rats. Toxics, 2, 496-532, 2014.

Stoner, R., Chow, M.L., Boyle, M.P., Sunkin, S.M., Mouton, P.R., Roy, S., Wynshaw-Boris, A., Colamarino, S., Lein, E.S., Courchesne, E. Discrete Patches of Laminar Disorganization in Young Autistic Neocortex, New England Journal of Medicine, January, 2014.

Mouton, P.R., NeurostereologyWiley-Blackwell Press, Boston, 280 pages, November 2013.

Manaye, K.F., Mouton, P.R., Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age 35: 139-147, 2013.

Selenica, M-L. B., Alvarez, J.A., Nash, K.R., Lee, D.C., Cao, C., Lin, X., Reid, P., Mouton, P.R., Morgan, D.,  Gordon, M.N. Diverse Activation Of Microglia By Chemokine (C-C Motif) Ligand 2 Overexpression In Brain. Journal Of Neuroinflammation, 10:86, 2013.

Chaudhury, B., Kramer, K., Elozory, D., Hernandez, G., Goldgof, D., Hall, L.O., Mouton, P.R. A Novel Algorithm For Automated Counting Of Stained Cells On Thick Tissue Sections. In 25th International Symposium on Computer-based Medical Systems (CBMS) (Rome, Italy), pp. 1-6. IEEE, 2012.

Elozory, D.T., Bonam, O.P., Kramer, K., Goldgof, D., Hall, L., Mangual, O., Mouton, P.R. Automatic Section Thickness Determination Using An Absolute Gradient Focus Function. J Microsc, 248(3): 245-59, 2012.

Mouton, P.R., Kelley-Bell, B., Tweedie, D., Spangler, E., Perez, E., Carlson, O.D., Short, R.G., Decabo, R., Chang, J., Ingram, D.K., Li, Y., Greig, N.H. Effects Of Age And LPS-Mediated Inflammation On Central Catecholaminergic Neuron Number In B6 Mice. Neurobiology Of Aging, 423:27-36, 2012.

Manaye, K.F., Mouton, P.R., Xu, G., Drew, A., Lei, D-L, Yukti, S., Rebeck, G.W., Turner, S., Alzheimer’s Type Neuron Loss In Locus Coeruleus Of Triple Transgenic Mice. AGE, November 30, 2011.

Courchesne, E., Mouton, P.R., Calhoun, M.E., Semendeferi, K., Ahrens-Barbeau, C., Carter, C., Pierce, K. Neuron Number And Size In Prefrontal Cortex Of Children With Autism. Journal Of The American Medical Association (JAMA), 306 (18):2001-10, November 9, 2011.

Bonam, O., Elozory, D., Kramer, K., Goldgof, D., Hall, L.O., Mangual, O. Mouton, P.R. Toward automated quantification of biological microstructures using unbiased stereology, Proc. SPIE, vol.7963, 2011.

Mouton, P.R. Unbiased Stereology: A Concise Guide. The Johns Hopkins University Press, Baltimore, August, 2011.

Mouton, P.R. Applications Of Unbiased Stereology To Neurodevelopmental Toxicology, In Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies And Mechanisms (C. Wang And W. Slikke, Eds), John Wiley & Sons, Hoboken, N.J. pg. 53-77, 2011.

Manaye, K.F., Kalifa, S., Drew, A.C., Edossa, A., Lei, D-L, Ingram, D.K., Mouton, P.R. 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. Journal of Alzheimer’s Disease, 23:629-39, December 2010.

Mouton, P.R., Gordon, M. Stereological And Image Analysis Techniques For Quantitative Assessment Of Neurotoxicology. In Neurotoxicology, 3rd Edition, Target Organ Toxicology Series, G. Jean Harry, Hugh A. Tilson, (Eds), Taylor & Francis Press, London And New York, pp. 243-267, March 2010.

Mouton, P.R. Applications Of Modern Stereology To Quantitative Microscopy, In Microscopy And Microanalysis, L.N. Brewer, S. Mackernan, J.P. Shields, et al., (Eds.), Cambridge University Press, London, Pp. 1526-1527, 2009.

Mouton, P.R., Chachich, M.E., Quigley, C., Spangler, E., Ingram, D.K. Caloric Restriction Attenuates Cortical Amyloidosis In A Double Transgenic Mouse Model Of Alzheimer’s Disease. Neuroscience Lett 464:184-7, 2009.

Burke, M, Zangenehpour, S, Mouton PR, Ptito, M. Knowing What Counts: Unbiased Stereology In The Non-Human Primate Brain. J Vis Exp. 2009 May 14; (27) 1262-1266. Video: Http://Www.Jove.Com/Index/Details.Stp?ID=1262.

Duffy, K.B, Spangler E.L., Devan B.D., Guo Z., Bowker J.L., Janas, A.M., Hagepanos, A., Minor, R.K., Decabo R., Mouton, P.R., Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. A Blueberry-Enriched Diet Provides Cellular Protection Against Oxidative Stress And Reduces A Kainate-Induced Learning Impairment In Rats. Neurobiol Aging. 29:1680-9, 2008.

Berman, R.F., Pessah, I.N., Mouton, P.R. Mav, D., Harry, G.J. Low Level Neonatal Thimerosal Exposure: Further Evaluation Of Altered Neurotoxic Potential In SJL Mice. Toxicol. Sci. 101(2): 294-309, 2008.

Manaye, K.F., Wang, P., O’Neil, J., Huafu, S., Tizabi, Y., Thompson, N., Ottinger, M.A., Ingram, D.K., Mouton, P.R. Neuropathological Quantification Of Dtg APP/PS1. AGE 29:87-96, 2007.

O’Neil, J.N., Mouton, P.R., Tizabi Y., Ottinger, M.A., Lei, D-L., Ingram, D.K., Manaye, K.F. Catecholaminergic Neuron Number In Locus Coeruleus Of Aged Female Dtg App/Ps1 Mice. J. Chem.Neuroanat. 34(3-4): 102-7, 2007.

Perry, T.A., Holloway, H.W., Weerasuriya, A., Mouton, P.R., Duffy, K., Mattison J.A. Evidence Of GLP-1-Mediated Neuroprotection In An Animal Model Of Pyridoxine-Induced Peripheral Sensory Neuropathy. Exp Neurol 203:293-301, 2007.

Francis HW, Rivas A, Lehar M, Saito Y, Mouton PR, Ryugo DK. Efficient Quantification Of Afferent Cochlear Ultrastructure Using Design-Based Stereology. J Neurosci Methods.150: 150-8, 2006.

Kruman II, Mouton P.R., Emokpae E, Cutler RG, Mattson MP. Folate Deficiency Inhibits Proliferation Of Adult Hippocampal Progenitors. Neuroreport,13:1055-9, 2005.

Manaye KF, Lei DL, Tizabi Y, Davila-Garcia MI, Mouton PR, Kelly PH. Selective Cell Loss In The Hypothalamus Of Patients Suffering From Depression. J Neuropath Exp Neurol 64:224-9, 2005.

Mouton PR, Durgavich J, Ingram, DK. Automatic Estimation Of Size Parameters Using Verified Computerized Stereoanalysis, Image Annals Stereol 2005; 24:1-9

Marcario JK, Manaye KF, Santacruz KS, Mouton PR, Berman NEJ, Cheney PD. Severe Subcortical Degeneration In Macaques Infected With Neurovirulent Simian Immunodeficiency Virus. J Neurovirol 10:1-13, 2004.

Maswood, N. Young, J., Tilmont, E., Zhang, Z., Gash, D.M., Gerhardt, G.A., Grondin, R., Yi, A., Roth, G.S., Lane, M.A., Mattison, J., Cohen, R.M., Mouton, P.R., Quigley, C., Mattson, M.P., Ingram, D.K. Caloric Restriction Stimulates Production Of Neurotrophic Factors And Attenuates Neurochemical And Behavioral Deficits In A Primate Model Of Parkinson Disease. Proc. Natl. Acad. Sci. Usa 101(52):18171-6, 2004.

Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH. Pyridoxine-Induced Toxicity In Rats: A Stereological Quantification Of The Sensory Neuropathy. Exp Neurol 190:133-44, 2004.

Mouton PR, Long JM, Lei D-L, Howard V, Jucker M, Calhoun ME, Ingram DK. Age And Gender Effects On Microglia And Astrocyte Number In Brains Of Mice. Brain Res 956:30-35, 2002.

Mouton PR. Principles And Practices Of Unbiased Stereology: An Introduction For Bioscientists. The Johns Hopkins University Press, Baltimore, Maryland, May 2002.

Mouton PR, Gokhale AM, Ward NL, West MJ. Stereological Length Estimation Using Spherical Probes. J Microsc 206: 54-64, 2002.

Long JM, Mouton PR, Jucker M, Ingram DK. What Counts In Brain Aging? Design-Based Stereological Analysis Of Cell Number. J Gerontology 54A: B407-B417, 1999.

Long JM, Ingram DK, Kalehua A, Mouton, P.R.. Stereological Estimation Of Microglia Number In Hippocampal Formation Of The Mouse Brain. J Neurosci Meth 84: 101-108, 1998.

Mouton PR, Martin LJ, Calhoun ME, Dal Forno G, Troncoso JC, Price DL. Cognitive Decline Strongly Correlates With Cortical Atrophy In Alzheimer’s Dementia. Neurobiol Aging 19: 371-377, 1998.

Mouton PR, Price DL, Walker LC. Empirical Assessment Of Total Synapse Number In Primate Neocortex. J Neurosci Meth 75: 119-126, 1997.

Sisodia, S., Thinakaren, G., Van Koch, C., Slunt, H., Roskams, J., Kitt, C.A., Masliah, E., Koliatosos, V., Mouton P.R., Martin., L.J., Reed, R., Ronnett, G.V., Zheng, H., Van Der Ploeg, L., Price, D.L. In-Vivo Biology Of APP And Its Homologues. In Neurodegenerative Diseases: Molecular And Cellular Mechanisms And Therapeutic Approaches. (Gary Fiskum, Ed.), Plenum, New York. 485 Pp, 1996.

Mouton PR, Pakkenberg B, Gundersen HJG, Price Dl. Absolute Number And Size Of Pigmented Locus Coeruleus Neurons In The Brains Of Young And Aged Individuals. J Chem Neuroanat 7: 185-190,1994.

Mouton PR, Olson L. Nerve Growth Factor Increases The Size Of Intracortical Cholinergic Transplants. Acta Stereol 87: 376-381, 1993.

Pakkenberg B, Andersen BB, Jensen GB, Korbo L, Mouton PR, Møller A, Regeur L Øster S. The Impact Of The New Stereology On The Neurosciences —Neurostereology. Acta Stereol 11: 157-164, 1992.